Preparation of acetylsalicylic acid. Acetylsalicylic acid Test Purpose, Procedure, Result and more 2022-10-21
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Acetylsalicylic acid, more commonly known as aspirin, is a commonly used pain reliever and anti-inflammatory medication. It is often used to treat headaches, muscle aches, and other types of pain, as well as to reduce fever and inflammation. In this essay, we will discuss the preparation of acetylsalicylic acid, including the starting materials, the necessary equipment, and the steps involved in the synthesis process.
The main starting material for the synthesis of acetylsalicylic acid is salicylic acid, which is a natural compound found in plants such as willow bark and meadowsweet. Salicylic acid can be obtained by extraction from these plants, or it can be synthesized from other chemicals. Other starting materials that are needed for the synthesis of acetylsalicylic acid include acetic anhydride, a type of organic compound, and a base such as sodium hydroxide or potassium hydroxide.
To prepare acetylsalicylic acid, a variety of laboratory equipment is needed, including a flask, a condenser, a stirrer, and a heating device such as a hot plate or a Bunsen burner. The synthesis process typically begins by combining the salicylic acid, acetic anhydride, and base in the flask and heating the mixture until it reaches a temperature of around 80-85°C. The mixture is then stirred and allowed to cool.
Once the mixture has cooled, it is filtered to remove any solid impurities. The resulting solution is then treated with an acid, such as hydrochloric acid, which causes the acetylsalicylic acid to crystallize out of the solution. The crystals are then collected and dried to obtain the final product.
In summary, the preparation of acetylsalicylic acid involves the synthesis of salicylic acid, the combination of salicylic acid with acetic anhydride and a base, and the treatment of the resulting mixture with an acid to produce acetylsalicylic acid crystals. This process requires a variety of laboratory equipment and chemicals, and it is typically carried out in a controlled environment to ensure the safety of the personnel involved and the purity of the final product.
EXP 4 _ PREPARATION OF ACETYLSALICYLIC webapi.bu.edu
The obtained product was tested for unreacted salicylic acid. This indicates that there may have been impurities in the product. This result could have been due to errors when carrying out the procedure in the lab as mentioned before. Aspirin or acetylsalicylic acid ASA is widely used as a pain relief for mild aches and discomfort and to alleviate fever. Finally the water was poured to the paper to wet it and then the water aspirator was turned on to a maximum water flow and the solution in the beaker poured into the funnel. These impurities could also explain the differences in peak intensity and width in the infrared spectrum. Material after complete mix is subjected to tabletting by the flat stamping die of 12.
A 50mL beaker was weighed before placing the crystals and reweighing the beaker. . The reaction vial was then connected to a reflux heating set-up and allowed to boil for twenty minutes until the cloudy white color dissolved into a clear liquid and then was allowed to cool. However, due to miscommunication, the reactants used to spot the TLC plates were taken after heating had started. Download file to see next pages Read More This chemical is converted into salicylic acid once ingested by a person and is widely used to manufacture aspirin. S4, by the material direct tablet compressing after complete mix, detailed process is as follows: the material after complete mix is passed through the flat punch die of 10.
These mainly happen with higher doses of aspirin. . The crystals were washed with two portions of cold water each 5mL and then followed by a one 10mL portion of cold ethanol. . Naturally, they form like clear and colourless crystals of organic acid.
Add a minimum amount of hot acetyl acetate into the flask and gently heat the mixture on a steam bath. The Buchner funnel was inserted into the filter flask through a one-hole rubber stopper and a filter paper placed into the Buchner funnel making sure the paper covered all the holes. . In terms of 300,000, when aspirin is made of the raw material of following parts by weight: aspirin 142. Step 8: To purify the product perform recrystallization.
Preparation and functionalization of acetylsalicylic acid loaded chitosan/gelatin membranes from ethanol
These TLC plates were put into a developing chamber, in this case, a jar, containing a one to one ratio of Ethyl Acetate and Hexane. Acetylsalicylic acid commonly known as Aspirin is a prototypical analgesic with the chemical formula C 9H 8O 4. If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. Here, in this given reaction, acetylsalicylic acid is reacted with acetic anhydride in a given acidic environment that even leads to acetylation of the hydroxyl group that is present in acetylsalicylic acid, and it thereby leads to the production of acetylsalicylic acid aspirin the mass production of aspirin and must be removed from the resulting product by several refining processes. Above-mentioned acetylsalicylic acid tablet is mutually compounded by particular types with the raw material of specified weight part ratio, and powder can be used and directly press Piece does not easily cause aspirin degradation to generate salicylic acid on the whole, and quality stability is good, and dissolution rate is high. Once dry, the solid product in the funnel was weighed to determine the percent yield of the product.
Preparation and Purification of Acetylsalicylic Acid
Acetylsalicylic acid ASA is used to treat discomfort, nausea, and swelling of various symptoms such as lower back and neck discomfort, measles, chronic colds, burns, menstrual pain, depression, migraines, osteoarthritis, rheumatoid arthritis, sprains and strains, joint damage, toothache, shoulder pain and bursitis. Due to inconsistencies in the data and errors occurring while conducting the experiment, the final product was not successful. Wherein, raw material is crushed first, the specific surface area of material can be made to increase, it is wet It will use certain density adhesive when legal system grain, and introduce a large amount of water, inevitably result in a large amount of degradations of aspirin, Salicylic acid is generated, more side effect occurs in clinical use, for example lead to mucosal lesion, nausea,vomiting,diarrhea, head occurs Bitterly, situations such as dizziness, tinnitus. To crystallize the substance, cool the solution. Initial test on ASA were not… Acetic In the first part of this experiment acetic anhydride was used to prepare acetanilide which could then be readily brominated to form a mono-brominated product, with the bromine positioned at either the ortho, meta or para position on the aromatic ring.
Experiment 3: Preparation of Acetylsalicylic Acid Flashcards
Organic Chemistry 1 Preparing Acetylsalicylic Acid Crystals Abstract From the reaction shown seen below 1, we obtained 3. The crystals were placed between several sheets of filter paper using a spatula and press-dried. All the functional groups identified by the experimental and literature IR spectrum align with the acetylsalicylic molecule. It got its name from Latin word Acetum, which means vinegar. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed. Observation and comparisons were made from the three test tubes and recorded.
Buchner funnel and filter were set up for the filtration… Oil Of Wintergreen In this experiment, the Oil of Wintergreen is put into an Erlenmeyer flask containing sodium hydroxide to create sodium salicylate. Pure acetic acid is also called glacial acetic acid, because in winters it freezes easily as temperature goes below 16-17°C. Then, 10 milliliters of water weas added to the reaction mixture. Structures Observations The first reactant we used was salicylic acid, which had a white color and a thicker texture compared to powder, to me it looked like white small and thin sugar grains. If the peaks representing different functional groups match closely then, the intended product was most likely made correctly. This comparative example is provided a kind of acetylsalicylic acid tablet and is amounted to 100,000 comprising the supplementary material of following parts by weight: Ah Department woods 50Kg, interior plus auxiliary material: microcrystalline cellulose ZW102 type 0. Unless otherwise defined, institute used herein Some technical and scientific terms have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
